Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism
نویسندگان
چکیده
منابع مشابه
Early postnatal treatment of hypogonadotropic hypogonadism with recombinant human FSH and LH.
BACKGROUND Patients with hypogonadotropic hypogonadism may be diagnosed shortly after birth because of micropenis and cryptorchidism, combined with subnormal LH and FSH concentrations during the postnatal period. OBJECTIVE To investigate whether treating these patients with gonadotropins postnatally, to mimic the physiological development, would improve testicular growth and fertility potenti...
متن کاملP-166: Assisted Reproductive Techniques Outcomes in Hypogonadotropic Hypogonadism Women
Background: To evaluate the outcomes of using in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI cycle) techniques in hypogonadotropic hypogonadism women and comparing them to women with tubal factor infertility. Materials and Methods: Data from 81 hypogonadotropic hypogonadism (HH) patients treated with IVF/ICSI in the period from early 2009 until the end of 2010 were analyze...
متن کاملAnti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
Context Isolated hypogonadotropic hypogonadism (IHH), characterized by gonadotropin deficiency and absent puberty, is very rare in women. IHH prevents pubertal ovarian stimulation, but anti-Müllerian hormone (AMH) and antral follicle count (AFC) have not been studied. Objectives (1) To compare, in IHH vs controls, AMH, ovarian volume (OV), and AFC. (2) To compare, in IHH, ovarian responses to...
متن کاملR31C GNRH1 Mutation and Congenital Hypogonadotropic Hypogonadism
Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare reproductive disease leading to lack of puberty and infertility. Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH. R31C GNRH1 is the only missense mutation that affects the conserved GnRH decapeptide sequence. This mutation was identified in a CpG islet in nine nCHH subjects from four u...
متن کاملCongenital Hypogonadotropic Hypogonadism during Childhood: Presentation and Genetic Analyses in 46 Boys
BACKGROUND The majority of the patients reported with mutations in isolated hypogonadotropic hypogonadism (HH) are adults. We analysed the presentation and the plasma inhibin B and anti-müllerian hormone (AMH) concentrations during childhood and adolescence, and compared them to the genetic results. METHODS This was a retrospective, single-center study of 46 boys with HH. RESULTS Fourteen (...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2018
ISSN: 2472-1972
DOI: 10.1210/js.2018-00225